Full closure of Highway 41 is planned in Kings, Kern and San Luis Obispo counties, Caltrans said.
The closure will include Highway 41 from Highway 33 in Kings County to the Highway 41 and Highway 46 interchange in San Luis Obispo.
The detours will be in effect on Tuesday from 8 a.m. to 5 p.m.
Drivers going north can continue on eastbound Highway 46 to Highway 33 to Highway 41.
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Drivers headed south on Highway 41 can use the detour to Highway 33 to Highway 46.
The closure is planned due to guardrail repair, shoulder improvements, pavement replacements, vegetation controls and road sweeping.