Chris Johnson continues to live in the shadows of Adrian Peterson as the NFL's best running back, but the league's current leading rusher has earned a few headlines of his own for the Tennessee Titans.

Peyton Manning threw for 347 yards, but it was Joseph Addai that threw the game-winning TD pass to Reggie Wayne in the fourth quarter, as the Indianapolis Colts survived a tough test from the San Francisco 49ers and kept their undefeated season intact with an 18-14 victory at Lucas Oil Stadium.

San Francisco 49ers linebacker Takeo Spikes is questionable for Sunday's game at Indianapolis with a shoulder injury.

Peyton Manning and Alex Smith both have the distinction of being former No. 1 overall draft picks, but the careers of the two quarterbacks couldn't have gone any more differently up to this point.

The San Francisco 49ers signed cornerback Tarell Brown to a three-year contract extension, the team announced Wednesday.

The San Francisco 49ers put offensive lineman Tony Pashos on injured reserve Tuesday after he suffered a fractured scapula in Sunday's loss to the Texans.

San Francisco 49ers head coach Mike Singletary announced on Monday that Alex Smith will start at quarterback next week against the Indianapolis Colts.

Matt Schaub threw a pair of touchdown passes, and Steve Slaton scored twice, as the Houston Texans held off the San Francisco 49ers, 24-21, at Reliant Stadium.

Statistics aren't important to some players and coaches in the National Football League, but Houston Texans head coach Gary Kubiak has to be impressed with how his run defense has been playing lately.

The San Francisco 49ers have indicated rookie wide receiver Michael Crabtree will make his first appearance in the club's October 25th contest at Houston.

The San Francisco 49ers released return specialist Allen Rossum on Monday to make room on the roster for rookie wide receiver Michael Crabtree.

San Francisco 49ers safety Michael Lewis suffered an apparent concussion in the third quarter of Sunday's 45-10 loss to Atlanta.

Roddy White caught two touchdowns and Michael Turner rushed for three more -- all in the first half -- as Atlanta jumped all over the 49ers and cruised to a 45-10 victory.