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Columbus (4-4-3) at New York (7-4-3), 5 p.m. There is no MLS team in better form than Red Bull New York.
Sporting Kansas City and the Houston Dynamo will square for the second time in two weeks when the two Eastern Conference rivals meet at Sporting Park on Sunday.
Seattle Sounders FC bring a six-match unbeaten streak into its showdown at the Los Angeles Galaxy on Sunday in a rematch of last season's Western Conference final.
The New England Revolution will aim to continue their positive momentum on Saturday as the club hosts Toronto FC at Gillette Stadium.
The Colorado Rapids will hope to extend their unbeaten run to five games on Saturday when the club welcomes struggling Chivas USA to Dick's Sporting Goods Park.
Real Salt Lake begins a four-game homestand on Saturday when the Chicago Fire invades Rio Tinto Stadium.
San Jose (3-4-6) at FC Dallas (7-2-3), 8:30 p.m. A pair of Western Conference rivals meet on Saturday as the San Jose Earthquakes battle FC Dallas at FC Dallas Stadium.
The Philadelphia Union go in search of a potential season-defining victory on Saturday when the club heads north of the boarder to battle the Montreal Impact at Saputo Stadium.
The Portland Timbers and D.C. United are two teams at complete opposite ends of the spectrum.
The MLS Disciplinary Committee handed Houston Dynamo defender Bobby Boswell an additional one-game suspension and fined him an undisclosed amount for violent conduct against New England Revolution forward Dimitry Imbongo.
The Portland Timbers announced on Wednesday that the club has signed defender Rauwshan McKenzie, while also waiving defender Ryan Kawulok.
After being introduced as Major League Soccer's 20th franchise, New York City Football Club made its first personnel decision on Wednesday, hiring former United States international Claudio Reyna as director of football.
Major League Soccer Commissioner Don Garber announced Tuesday that Manchester City and the New York Yankees have combined efforts to acquire the League's 20th expansion club.
Seattle Sounders forward Eddie Johnson was named the Player of the Week on Monday for Week 12 of the 2013 Major League Soccer season.
This past weekend's Major League Soccer action saw the continuation of some impressive -- and some not-so-impressive -- streaks as the Portland Timbers are on cruise control, while D.C. United keeps struggling as we look back on Week 12 in MLS.
Ned Grabavoy scored his first two goals of the season on Sunday to lead Real Salt Lake to a 4-1 win over Chivas USA at The Home Depot Center.
D.C. United's winless run in league play reached nine consecutive matches on Sunday after the club battled to a 1-1 draw with Sporting Kansas City at RFK Stadium.
Red Bull New York left it late against the Los Angeles Galaxy on Sunday as Tim Cahill scored at the death in a 1-0 victory at Red Bull Arena.
A stunning free kick from Marvin Chavez in the 78th minute allowed the San Jose Earthquakes to claim a 1-1 draw with the Colorado Rapids at Buck Shaw Stadium on Saturday.
Seattle Sounders FC is starting to hit its stride after the club secured a 4-2 win over the Western Conference leaders, FC Dallas, at CenturyLink Field on Saturday.
After a 36-game home unbeaten run, the Houston Dynamo has now lost two straight games at BBVA Compass Stadium after a 2-0 defeat to the New England Revolution on Saturday.
Jack McInerney scored the only goal of the match to lift the Philadelphia Union to a 1-0 win over the Chicago Fire on a rainy night at PPL Park.
A great individual effort from Jose Valencia in the 84th minute helped 10-man Portland Timbers claim a 2-2 draw against Cascadia Cup rivals Vancouver Whitecaps FC at BC Place on Saturday.
Dominic Oduro's tally late in the first half was enough to lift the Columbus Crew to a 1-0 victory over Toronto FC on Saturday at BMO Field.
Real Salt Lake will cap a three-game road trip on Sunday at The Home Depot Center against a struggling Chivas USA side.